/*
Theme Name: Orphanika Child Theme
Theme URI: https://orphanika.org
Description: High-performance, accessible child theme for GeneratePress powering the Orphanika Rare Disease Platform with full multilingual support and complete clinical monographs.
Author: Orphanika Health Initiative
Author URI: https://orphanika.org
Template: generatepress
Version: 1.5.8
Text Domain: orphanika
*/

:root {
  /* Brand Color Palette */
  --orp-primary: #2F4858;       /* Deep slate-teal / petrol blue */
  --orp-primary-dark: #1E333F;  /* Contrast footer / header */
  --orp-accent: #F36633;        /* Warm GSK-inspired orange */
  --orp-accent-hover: #D95324;
  --orp-cyan: #7BA4B5;          /* Muted cyan / soft slate-blue */
  --orp-cyan-light: #EBF3F6;    /* Soft tinted card background */
  --orp-bg: #F8FAFB;            /* Soft reader-friendly background */
  --orp-surface: #FFFFFF;       /* Pure white card surface */
  --orp-text: #1E293B;          /* Charcoal body text */
  --orp-text-muted: #64748B;    /* Muted metadata */
  --orp-border: #E2E8F0;
  
  /* Geometry & Radii */
  --orp-radius-sm: 8px;
  --orp-radius-md: 14px;
  --orp-radius-lg: 20px;
  --orp-radius-pill: 9999px;
  
  /* Elevation */
  --orp-shadow-sm: 0 1px 3px rgba(47, 72, 88, 0.06);
  --orp-shadow-md: 0 4px 12px rgba(47, 72, 88, 0.08);
  --orp-shadow-lg: 0 10px 25px rgba(47, 72, 88, 0.10);
  
  /* Typography */
  --orp-font-heading: 'Plus Jakarta Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
  --orp-font-body: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
}

/* Global Reset & Typography */
body {
  font-family: var(--orp-font-body);
  background-color: var(--orp-bg);
  color: var(--orp-text);
  line-height: 1.7;
  -webkit-font-smoothing: antialiased;
}

h1, h2, h3, h4, h5, h6 {
  font-family: var(--orp-font-heading);
  color: var(--orp-primary);
  font-weight: 700;
  letter-spacing: -0.02em;
}

/* Soft Rounded Card UI */
.orphanika-card {
  background: var(--orp-surface);
  border: 1px solid var(--orp-border);
  border-radius: var(--orp-radius-md);
  padding: 24px;
  box-shadow: var(--orp-shadow-sm);
  transition: transform 0.2s ease, box-shadow 0.2s ease, border-color 0.2s ease;
  position: relative;
  overflow: hidden;
}

.orphanika-card:hover {
  transform: translateY(-2px);
  box-shadow: var(--orp-shadow-md);
  border-color: var(--orp-cyan);
}

/* Cyan Top Accent Line */
.orphanika-card--accent {
  border-top: 4px solid var(--orp-cyan);
}

/* Hero Section with Soft Curves */
.orphanika-hero {
  background: linear-gradient(135deg, var(--orp-primary) 0%, var(--orp-primary-dark) 100%);
  color: #ffffff;
  padding: 80px 24px 100px;
  position: relative;
  border-bottom-left-radius: var(--orp-radius-lg);
  border-bottom-right-radius: var(--orp-radius-lg);
}

.orphanika-hero h1 {
  color: #ffffff;
  font-size: 2.8rem;
  font-weight: 800;
}

.orphanika-hero p {
  color: #E2E8F0;
  font-size: 1.2rem;
  max-width: 680px;
}

/* Soft Wavy Divider */
.orphanika-wave-divider {
  position: absolute;
  bottom: 0;
  left: 0;
  width: 100%;
  overflow: hidden;
  line-height: 0;
}

.orphanika-wave-divider svg {
  position: relative;
  display: block;
  width: calc(100% + 1.3px);
  height: 48px;
}

.orphanika-wave-divider .shape-fill {
  fill: var(--orp-bg);
}

/* A-Z Alphabetical Filter Bar */
.orphanika-az-nav {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  margin: 30px 0;
  padding: 16px;
  background: var(--orp-surface);
  border: 1px solid var(--orp-border);
  border-radius: var(--orp-radius-pill);
  box-shadow: var(--orp-shadow-sm);
  justify-content: center;
}

.orphanika-az-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 36px;
  height: 36px;
  padding: 0 10px;
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 0.95rem;
  color: var(--orp-primary);
  border-radius: var(--orp-radius-pill);
  text-decoration: none;
  transition: all 0.15s ease;
}

.orphanika-az-btn:hover,
.orphanika-az-btn.is-active {
  background: var(--orp-accent);
  color: #ffffff;
  transform: scale(1.05);
}

/* Badges & Pills */
.orphanika-badge {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  padding: 4px 12px;
  border-radius: var(--orp-radius-pill);
  font-size: 0.8rem;
  font-weight: 600;
  text-transform: uppercase;
  letter-spacing: 0.05em;
}

.orphanika-badge--cyan {
  background: var(--orp-cyan-light);
  color: var(--orp-primary);
  border: 1px solid var(--orp-cyan);
}

.orphanika-badge--orange {
  background: #FFF2EC;
  color: var(--orp-accent);
  border: 1px solid rgba(243, 102, 51, 0.3);
}

/* Accessibility Focus States */
a:focus-visible, button:focus-visible {
  outline: 3px solid var(--orp-accent);
  outline-offset: 2px;
  border-radius: 4px;
}

/* ==========================================================================
   Single Entity Layouts (MedlinePlus Layered Architecture)
   ========================================================================== */

.orphanika-entry-container {
  max-width: 1240px;
  margin: 0 auto;
  padding: 30px 20px 80px;
}

.orp-drug-hero {
  background: linear-gradient(135deg, var(--orp-primary) 0%, var(--orp-primary-dark) 100%);
  color: #ffffff;
  padding: 44px 36px;
  border-radius: var(--orp-radius-md);
  margin-bottom: 36px;
  box-shadow: var(--orp-shadow-md);
}

.orp-breadcrumbs {
  font-size: 0.85rem;
  color: rgba(255, 255, 255, 0.7);
  margin-bottom: 14px;
}

.orp-breadcrumbs a {
  color: #ffffff;
  text-decoration: none;
  font-weight: 500;
}

.orp-breadcrumbs a:hover {
  text-decoration: underline;
}

.orp-hero-badge-group {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
  margin-bottom: 12px;
}

.orp-entry-title {
  color: #ffffff !important;
  font-size: 2.3rem;
  font-weight: 800;
  margin: 0 0 16px 0;
  line-height: 1.25;
}

.orp-synonyms-bar {
  display: flex;
  flex-wrap: wrap;
  gap: 20px;
  font-size: 0.95rem;
  color: #E2E8F0;
  border-top: 1px solid rgba(255, 255, 255, 0.15);
  padding-top: 14px;
}

/* Two Column Grid */
.orp-two-col-layout {
  display: grid;
  grid-template-columns: 1fr 340px;
  gap: 32px;
  align-items: start;
}

@media (max-width: 900px) {
  .orp-two-col-layout {
    grid-template-columns: 1fr;
  }
}

/* Main Content & Section Cards */
.orp-main-content {
  display: flex;
  flex-direction: column;
  gap: 28px;
}

.orp-section-card {
  padding: 30px;
}

.orp-section-title {
  display: flex;
  align-items: center;
  gap: 12px;
  font-size: 1.35rem;
  margin-top: 0;
  margin-bottom: 20px;
  padding-bottom: 12px;
  border-bottom: 2px solid var(--orp-bg);
}

.orp-icon-pill {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 30px;
  height: 30px;
  background: var(--orp-cyan-light);
  color: var(--orp-primary);
  border-radius: var(--orp-radius-pill);
  font-size: 0.9rem;
  font-weight: 800;
  flex-shrink: 0;
}

.orp-lead-text {
  font-size: 1.05rem;
  line-height: 1.75;
  color: var(--orp-text);
  margin-bottom: 20px;
}

.orp-content-block p {
  margin-bottom: 16px;
  line-height: 1.7;
}

.orp-content-block a {
  color: var(--orp-primary);
  font-weight: 600;
  text-decoration: underline;
  text-decoration-color: rgba(47, 72, 88, 0.35);
  text-underline-offset: 3px;
  transition: all 0.15s ease;
}

.orp-content-block a:hover {
  color: var(--orp-accent, #F36633);
  text-decoration-color: var(--orp-accent, #F36633);
}

.orp-content-block ul,
.orp-content-block ol {
  margin: 12px 0 18px 24px;
  padding: 0;
  line-height: 1.7;
}

.orp-content-block li {
  margin-bottom: 6px;
}

.orp-subcard {
  background: var(--orp-bg);
  border-left: 4px solid var(--orp-cyan);
  padding: 20px;
  border-radius: var(--orp-radius-sm);
  margin-top: 20px;
}

.orp-subcard-title {
  font-size: 1.05rem;
  margin-top: 0;
  margin-bottom: 8px;
  color: var(--orp-primary);
}

/* Warnings & Precautions Box */
.orp-card--warning {
  border-color: #FED7AA;
  background: #FFFBF7;
}

.orp-text--warning {
  color: #C2410C !important;
}

.orp-icon-pill--warning {
  background: #FFEDD5;
  color: #C2410C;
}

/* Designations List */
.orp-designations-list {
  display: flex;
  flex-direction: column;
  gap: 14px;
}

.orp-designation-item {
  padding: 16px 20px;
  background: var(--orp-bg);
  border-radius: var(--orp-radius-sm);
  border: 1px solid var(--orp-border);
  transition: all 0.2s ease;
}

.orp-designation-item:hover {
  border-color: var(--orp-cyan);
  background: #ffffff;
}

.orp-designation-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 12px;
  margin-bottom: 8px;
}

.orp-disease-link {
  font-size: 1.1rem;
  color: var(--orp-primary);
  text-decoration: none;
}

.orp-disease-link:hover {
  color: var(--orp-accent);
  text-decoration: underline;
}

.orp-designation-text {
  margin: 0;
  font-size: 0.95rem;
  color: var(--orp-text);
  line-height: 1.5;
}

/* Tables */
.orp-table-responsive {
  overflow-x: auto;
}

.orp-data-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.95rem;
}

.orp-data-table th {
  background: var(--orp-bg);
  color: var(--orp-primary);
  text-align: left;
  padding: 12px 16px;
  font-weight: 700;
  border-bottom: 2px solid var(--orp-border);
}

.orp-data-table td {
  padding: 12px 16px;
  border-bottom: 1px solid var(--orp-border);
  vertical-align: middle;
}

.orp-data-table tr:hover td {
  background: #FAFDFE;
}

.orp-table-link {
  color: var(--orp-primary);
  text-decoration: none;
}

.orp-table-link:hover {
  color: var(--orp-accent);
  text-decoration: underline;
}

.orp-frequency-tag {
  display: inline-block;
  background: var(--orp-bg);
  padding: 3px 10px;
  border-radius: var(--orp-radius-pill);
  font-size: 0.85rem;
  font-weight: 600;
  color: var(--orp-primary);
}

/* Notice Box */
.orp-notice-box {
  padding: 16px 20px;
  background: var(--orp-cyan-light);
  border-radius: var(--orp-radius-sm);
  color: var(--orp-primary);
  font-size: 0.95rem;
}

/* Sidebar Elements */
.orp-sidebar {
  display: flex;
  flex-direction: column;
  gap: 24px;
}

.orp-quick-facts-card {
  padding: 24px;
}

.orp-sidebar-title {
  font-size: 1.15rem;
  margin-top: 0;
  margin-bottom: 16px;
  padding-bottom: 10px;
  border-bottom: 1px solid var(--orp-border);
}

.orp-sidebar-subtitle {
  font-size: 0.95rem;
  font-weight: 700;
  margin: 14px 0 6px;
  color: var(--orp-primary);
}

.orp-facts-list {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 12px;
}

.orp-facts-list li {
  display: flex;
  flex-direction: column;
  gap: 2px;
  font-size: 0.9rem;
}

.orp-fact-label {
  color: var(--orp-text-muted);
  font-size: 0.8rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  font-weight: 600;
}

.orp-fact-val {
  color: var(--orp-text);
  word-break: break-word;
}

.orp-divider {
  border: 0;
  height: 1px;
  background: var(--orp-border);
  margin: 20px 0;
}

.orp-tag-group {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  align-items: center;
}

.orp-tag-heading {
  font-size: 0.8rem;
  font-weight: 700;
  color: var(--orp-text-muted);
  width: 100%;
}

.orp-gene-links-list {
  list-style: none;
  padding: 0;
  margin: 10px 0 0;
  display: flex;
  flex-direction: column;
  gap: 8px;
}

.orp-gene-tag {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  color: var(--orp-primary);
  text-decoration: none;
  padding: 6px 10px;
  background: var(--orp-bg);
  border-radius: var(--orp-radius-sm);
  font-size: 0.9rem;
}

.orp-gene-tag:hover {
  background: var(--orp-cyan-light);
  color: var(--orp-accent);
}

.orp-text-xs {
  font-size: 0.8rem;
  line-height: 1.5;
}

.orp-disclaimer-card {
  padding: 16px 20px;
  background: #F1F5F9;
  border-radius: var(--orp-radius-sm);
}

/* ==========================================================================
   Header, Navigation, Search Toggle & Language Switcher
   ========================================================================== */

/* Single Clean Site Header */
.orp-site-header {
  background: var(--orp-surface);
  border-bottom: 1px solid var(--orp-border);
  padding: 14px 24px;
  position: relative;
  z-index: 100;
}

.orp-header-inner {
  max-width: 1240px;
  margin: 0 auto;
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 24px;
}

.orp-site-branding {
  flex-shrink: 0;
}

.orp-brand-link {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  text-decoration: none;
  color: var(--orp-primary);
}

.orp-brand-logo-img {
  height: 34px;
  width: auto;
  max-height: 38px;
  display: block;
  object-fit: contain;
  transition: transform 0.2s ease;
}

.orp-brand-link:hover .orp-brand-logo-img {
  transform: scale(1.03);
}

.orp-brand-name {
  font-family: var(--orp-font-heading);
  font-weight: 800;
  font-size: 1.55rem;
  letter-spacing: -0.03em;
  color: var(--orp-primary);
}

.orp-primary-nav {
  display: flex;
  align-items: center;
  flex: 1;
  justify-content: flex-end;
}

.orp-primary-nav .orp-main-menu {
  display: flex;
  align-items: center;
  list-style: none;
  margin: 0;
  padding: 0;
  gap: 22px;
}

.orp-primary-nav .orp-main-menu > li {
  position: relative;
  list-style: none;
  margin: 0;
  padding: 0;
}

.orp-primary-nav .orp-main-menu > li:not(.orp-menu-support-item) > a:not(.orp-btn-support-nav),
.orp-dropdown-toggle {
  font-family: var(--orp-font-heading);
  font-weight: 650;
  font-size: 0.95rem;
  color: var(--orp-primary);
  text-decoration: none;
  padding: 8px 0;
  transition: color 0.15s ease;
  white-space: nowrap;
  background: none;
  border: none;
  cursor: pointer;
  display: inline-flex;
  align-items: center;
  gap: 6px;
}

.orp-primary-nav .orp-main-menu > li:not(.orp-menu-support-item) > a:not(.orp-btn-support-nav):hover,
.orp-dropdown-toggle:hover,
.orp-menu-item-has-children:hover .orp-dropdown-toggle,
.orp-menu-item-has-children.is-active .orp-dropdown-toggle {
  color: var(--orp-accent);
}

.orp-dropdown-arrow {
  stroke: currentColor;
  transition: transform 0.2s cubic-bezier(0.16, 1, 0.3, 1);
}

.orp-menu-item-has-children:hover .orp-dropdown-arrow,
.orp-menu-item-has-children.is-active .orp-dropdown-arrow {
  transform: rotate(180deg);
}

.orp-menu-item-has-children::after {
  content: '';
  position: absolute;
  top: 100%;
  left: 0;
  width: 100%;
  height: 14px;
  display: block;
}

.orp-dropdown-menu {
  position: absolute;
  top: calc(100% + 8px);
  left: -12px;
  min-width: 230px;
  background: #FFFFFF;
  border: 1px solid var(--orp-border);
  border-radius: 10px;
  padding: 8px;
  margin: 0;
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: 3px;
  box-shadow: 0 10px 25px -4px rgba(47, 72, 88, 0.12), 0 4px 10px -2px rgba(47, 72, 88, 0.05);
  opacity: 0;
  visibility: hidden;
  pointer-events: none;
  transform: translateY(6px);
  transition: all 0.18s cubic-bezier(0.16, 1, 0.3, 1);
  z-index: 1000;
}

.orp-menu-item-has-children:hover .orp-dropdown-menu,
.orp-menu-item-has-children:focus-within .orp-dropdown-menu,
.orp-menu-item-has-children.is-active .orp-dropdown-menu {
  opacity: 1;
  visibility: visible;
  pointer-events: auto;
  transform: translateY(0);
}

.orp-dropdown-menu li {
  display: block;
  width: 100%;
  margin: 0;
  padding: 0;
  list-style: none;
}

.orp-dropdown-menu a {
  display: flex;
  align-items: center;
  gap: 10px;
  padding: 9px 12px;
  font-family: var(--orp-font-heading);
  font-weight: 600;
  font-size: 0.92rem;
  color: var(--orp-primary);
  text-decoration: none;
  border-radius: 6px;
  white-space: nowrap;
  transition: all 0.15s ease;
}

.orp-dropdown-menu a:hover {
  background-color: var(--orp-bg);
  color: var(--orp-accent);
  transform: translateX(3px);
}

.orp-dd-icon {
  font-size: 1.05rem;
  line-height: 1;
  flex-shrink: 0;
}

/* Orange Button: Support the project */
.orp-menu-support-item {
  display: flex !important;
  align-items: center !important;
}

.orp-primary-nav .orp-main-menu > li.orp-menu-support-item > a.orp-btn-support-nav,
a.orp-btn-support-nav {
  display: inline-flex !important;
  align-items: center !important;
  justify-content: center !important;
  gap: 7px !important;
  background: #F36633 !important;
  background: linear-gradient(135deg, var(--orp-accent) 0%, #E05320 100%) !important;
  background-color: var(--orp-accent) !important;
  color: #FFFFFF !important;
  font-family: var(--orp-font-heading) !important;
  font-weight: 700 !important;
  font-size: 0.88rem !important;
  line-height: 1 !important;
  padding: 9px 18px !important;
  border-radius: 999px !important;
  box-shadow: 0 2px 8px rgba(243, 102, 51, 0.3) !important;
  text-decoration: none !important;
  transition: all 0.2s cubic-bezier(0.16, 1, 0.3, 1) !important;
  white-space: nowrap !important;
  border: none !important;
}

.orp-primary-nav .orp-main-menu > li.orp-menu-support-item > a.orp-btn-support-nav *,
a.orp-btn-support-nav * {
  color: #FFFFFF !important;
}

.orp-primary-nav .orp-main-menu > li.orp-menu-support-item > a.orp-btn-support-nav:hover,
a.orp-btn-support-nav:hover {
  background: #FF7744 !important;
  background: linear-gradient(135deg, #FF7744 0%, #EB5B26 100%) !important;
  background-color: #FF7744 !important;
  box-shadow: 0 4px 14px rgba(243, 102, 51, 0.45) !important;
  transform: translateY(-1px) !important;
  color: #FFFFFF !important;
}

.orp-primary-nav .orp-main-menu > li.orp-menu-support-item > a.orp-btn-support-nav:hover *,
a.orp-btn-support-nav:hover * {
  color: #FFFFFF !important;
}

.orp-primary-nav .orp-main-menu > li.orp-menu-support-item > a.orp-btn-support-nav:visited,
a.orp-btn-support-nav:visited {
  color: #FFFFFF !important;
}

.orp-btn-heart {
  font-size: 0.95rem;
  line-height: 1;
  transition: transform 0.2s ease;
}

.orp-btn-support-nav:hover .orp-btn-heart {
  transform: scale(1.2);
}

.orp-header-controls {
  display: flex;
  align-items: center;
  gap: 12px;
  flex-shrink: 0;
}

/* Search Toggle Button */
.orp-search-toggle-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 38px;
  height: 38px;
  background: var(--orp-surface);
  border: 1px solid var(--orp-border);
  border-radius: var(--orp-radius-sm);
  cursor: pointer;
  box-shadow: var(--orp-shadow-sm);
  transition: all 0.2s ease;
}

.orp-search-toggle-btn:hover {
  background: var(--orp-cyan-light);
  border-color: var(--orp-cyan);
}

/* Compact Flat Dropdown Language Switcher */
.orp-lang-dropdown-wrapper {
  position: relative;
  display: inline-block;
}

.orp-lang-select {
  appearance: none;
  -webkit-appearance: none;
  background: #FFFFFF url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='12' fill='%232F4858' viewBox='0 0 16 16'%3E%3Cpath d='M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z'/%3E%3C/svg%3E") no-repeat calc(100% - 10px) center;
  border: 1px solid var(--orp-border);
  border-radius: var(--orp-radius-sm);
  padding: 6px 28px 6px 12px;
  font-family: var(--orp-font-heading);
  font-size: 0.85rem;
  font-weight: 700;
  color: var(--orp-primary);
  cursor: pointer;
  outline: none;
  box-shadow: var(--orp-shadow-sm);
  transition: border-color 0.2s ease, box-shadow 0.2s ease;
}

.orp-lang-select:hover,
.orp-lang-select:focus {
  border-color: var(--orp-cyan);
}

/* Footer Dark Language Switcher */
.orp-lang-dropdown--footer .orp-lang-select--footer {
  background: #253C49 url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='12' fill='%23FFFFFF' viewBox='0 0 16 16'%3E%3Cpath d='M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z'/%3E%3C/svg%3E") no-repeat calc(100% - 10px) center;
  border: 1px solid rgba(255, 255, 255, 0.2);
  color: #FFFFFF;
  margin-top: 10px;
}

/* Expandable Search Drawer */
.orp-header-search-drawer {
  background: var(--orp-bg);
  border-top: 1px solid var(--orp-border);
  padding: 16px 24px;
}

.orp-header-search-container {
  max-width: 720px;
  margin: 0 auto;
}

.orp-search-input-wrap {
  position: relative;
  display: flex;
  align-items: center;
}

.orp-input-icon {
  position: absolute;
  left: 16px;
  font-size: 1rem;
  color: var(--orp-text-muted);
}

.orp-header-search-input {
  width: 100%;
  padding: 12px 110px 12px 46px !important;
  border: 1px solid var(--orp-border) !important;
  border-radius: var(--orp-radius-pill) !important;
  font-size: 0.95rem !important;
  background: #FFFFFF !important;
}

.orp-header-search-submit {
  position: absolute;
  right: 6px;
  background: var(--orp-accent);
  color: #FFFFFF;
  border: none;
  padding: 8px 18px;
  border-radius: var(--orp-radius-pill);
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 0.85rem;
  cursor: pointer;
  transition: background 0.15s ease;
}

.orp-header-search-submit:hover {
  background: var(--orp-accent-hover);
}

/* ==========================================================================
   Homepage Hero (Full-Width, Light Slate-Cyan Background, Centered)
   ========================================================================== */
.orp-home-hero {
  background: #E8F0F3;
  color: var(--orp-primary);
  text-align: center;
  padding: 60px 24px 70px;
  width: 100%;
}

.orp-home-hero-inner {
  max-width: 900px;
  margin: 0 auto;
}

.orp-home-hero-title {
  font-size: 2.6rem;
  font-weight: 800;
  line-height: 1.25;
  color: var(--orp-primary) !important;
  margin-bottom: 16px;
}

.orp-home-hero-subtitle {
  font-size: 1.15rem;
  color: var(--orp-text);
  margin-bottom: 32px;
  line-height: 1.6;
}

.orp-home-search-wrapper {
  max-width: 720px;
  margin: 0 auto;
  position: relative;
}

.orp-input-with-icon {
  position: relative;
  display: flex;
  align-items: center;
}

.orp-search-icon {
  position: absolute;
  left: 20px;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  pointer-events: none;
}

.orp-home-search-input {
  width: 100%;
  padding: 16px 130px 16px 54px !important;
  border-radius: var(--orp-radius-pill) !important;
  border: 1px solid rgba(47, 72, 88, 0.2) !important;
  font-size: 1.05rem !important;
  background: #FFFFFF !important;
  color: var(--orp-text) !important;
  box-shadow: 0 4px 14px rgba(47, 72, 88, 0.08) !important;
  transition: all 0.2s ease;
}

.orp-home-search-input:focus {
  border-color: var(--orp-accent) !important;
  outline: none;
}

.orp-search-submit-btn {
  position: absolute;
  right: 8px;
  background: var(--orp-accent);
  color: #FFFFFF;
  border: none;
  padding: 10px 24px;
  border-radius: var(--orp-radius-pill);
  font-family: var(--orp-font-heading);
  font-weight: 700;
  cursor: pointer;
  transition: background 0.2s ease;
}

.orp-search-submit-btn:hover {
  background: var(--orp-accent-hover);
}

/* Homepage Entity Grid */
.orp-home-entities-section {
  padding: 50px 24px;
}

.orp-home-container {
  max-width: 1240px;
  margin: 0 auto;
}

.orp-entity-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 24px;
}

@media (max-width: 960px) {
  .orp-entity-grid {
    grid-template-columns: repeat(2, 1fr);
  }
}

@media (max-width: 580px) {
  .orp-entity-grid {
    grid-template-columns: 1fr;
  }
}

.orp-entity-card {
  text-decoration: none;
  display: flex;
  flex-direction: column;
  height: 100%;
}

.orp-card--drug-accent {
  border-top: 4px solid var(--orp-accent);
}

.orp-card-icon-box {
  width: 48px;
  height: 48px;
  display: flex;
  align-items: center;
  justify-content: center;
  font-size: 1.5rem;
  border-radius: var(--orp-radius-sm);
  margin-bottom: 16px;
}

.orp-icon-box--cyan { background: var(--orp-cyan-light); }
.orp-icon-box--orange { background: #FFF2EC; }
.orp-icon-box--amber { background: #FEF3C7; }
.orp-icon-box--purple { background: #EDE9FE; }

.orp-card-number {
  font-family: var(--orp-font-heading);
  font-size: 2rem;
  font-weight: 800;
  color: var(--orp-primary);
  line-height: 1;
  margin-bottom: 8px;
}

.orp-card-title {
  font-size: 1.25rem;
  margin: 0 0 8px 0;
  color: var(--orp-primary);
}

.orp-card-desc {
  font-size: 0.9rem;
  color: var(--orp-text-muted);
  line-height: 1.5;
  margin-bottom: 18px;
  flex-grow: 1;
}

.orp-card-arrow {
  font-size: 0.85rem;
  font-weight: 700;
  color: var(--orp-accent);
}

/* Homepage A-Z Box */
.orp-home-az-section {
  padding: 0 24px 70px;
}

.orp-home-az-card {
  padding: 36px;
}

.orp-az-section-heading {
  margin-top: 0;
  font-size: 1.4rem;
}

/* Footer Styles */
.orp-site-footer {
  background: var(--orp-primary-dark);
  color: #94A3B8;
  padding: 60px 24px 20px;
  border-top: 1px solid rgba(255, 255, 255, 0.08);
}

.orp-footer-inner {
  max-width: 1240px;
  margin: 0 auto;
  display: grid;
  grid-template-columns: 1.5fr 1fr 1fr 1.5fr;
  gap: 40px;
  padding-bottom: 40px;
  border-bottom: 1px solid rgba(255, 255, 255, 0.08);
}

@media (max-width: 900px) {
  .orp-footer-inner {
    grid-template-columns: 1fr 1fr;
  }
}

@media (max-width: 580px) {
  .orp-footer-inner {
    grid-template-columns: 1fr;
  }
}

.orp-brand-link--footer .orp-brand-name {
  color: #FFFFFF;
}

.orp-footer-desc {
  font-size: 0.9rem;
  line-height: 1.6;
  margin-top: 14px;
}

.orp-footer-title {
  color: #FFFFFF;
  font-size: 1rem;
  margin-top: 0;
  margin-bottom: 18px;
}

.orp-footer-links {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 10px;
  font-size: 0.9rem;
}

.orp-footer-links a {
  color: #94A3B8;
  text-decoration: none;
  transition: color 0.15s ease;
}

.orp-footer-links a:hover {
  color: #FFFFFF;
}

.orp-footer-disclaimer {
  font-size: 0.82rem;
  line-height: 1.6;
  background: rgba(255, 255, 255, 0.04);
  padding: 14px;
  border-radius: var(--orp-radius-sm);
  border-left: 3px solid var(--orp-accent);
}

.orp-footer-bottom {
  max-width: 1240px;
  margin: 20px auto 0;
  text-align: center;
  font-size: 0.8rem;
}

/* ==========================================================================
   Clinical Editorial Monograph Layout & Typography (v1.3.0)
   ========================================================================== */

/* Distinct Medical Links with GSK Cyan Underline */
.orp-clean-link,
.orp-editorial-flow a:not(.orphanika-badge),
.orp-top-disease-link,
.orp-facts-list a,
.orp-gene-facts-list a {
  color: #1B4965;
  text-decoration: underline 2px solid #7BA4B5;
  text-underline-offset: 3px;
  transition: color 0.15s ease, text-decoration-color 0.15s ease;
}

.orp-clean-link:hover,
.orp-editorial-flow a:not(.orphanika-badge):hover,
.orp-top-disease-link:hover,
.orp-facts-list a:hover,
.orp-gene-facts-list a:hover {
  color: #0E2A3A;
  text-decoration-color: var(--orp-accent);
}

/* Nav Support / Donate Link */
.orp-nav-support-link {
  color: var(--orp-accent) !important;
  font-weight: 750 !important;
}

/* Flat Editorial Monograph (No Island Cards Inside Main Content) */
.orp-editorial-flow {
  background: transparent;
}

.orp-editorial-section {
  margin-bottom: 34px;
  padding-bottom: 28px;
  border-bottom: 1px solid rgba(123, 164, 181, 0.25);
}

.orp-editorial-section:last-child {
  border-bottom: none;
  margin-bottom: 0;
  padding-bottom: 0;
}

.orp-section-subtitle {
  font-size: 1.15rem;
  color: var(--orp-primary);
  margin: 24px 0 14px;
}

/* Borderless Clean List Layout for Symptoms, Drugs & Genes */
.orp-clean-list {
  list-style: none;
  padding: 0;
  margin: 16px 0;
}

.orp-clean-list-item {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: 12px 0;
  border-bottom: 1px solid rgba(123, 164, 181, 0.2);
  gap: 16px;
  transition: background-color 0.15s ease;
}

.orp-clean-list-item:last-child {
  border-bottom: none;
}

.orp-clean-list-item:hover {
  background-color: rgba(235, 243, 246, 0.35);
}

.orp-clean-list-item--block {
  flex-direction: column;
  align-items: flex-start;
  gap: 6px;
}

.orp-list-header-row {
  display: flex;
  justify-content: space-between;
  align-items: center;
  width: 100%;
  gap: 12px;
}

.orp-list-item-main {
  display: flex;
  align-items: center;
  gap: 10px;
  flex-wrap: wrap;
  position: relative;
}

.orp-item-code-tag {
  font-size: 0.8rem;
  color: var(--orp-text-muted);
  background: var(--orp-bg);
  padding: 2px 8px;
  border-radius: var(--orp-radius-sm);
  border: 1px solid var(--orp-border);
}

.orp-brand-annotation {
  font-size: 0.88rem;
  color: var(--orp-text-muted);
  font-weight: 500;
}

.orp-badge-link {
  text-decoration: none !important;
  cursor: pointer;
  transition: transform 0.15s ease, background-color 0.15s ease;
}

.orp-badge-link:hover {
  transform: translateY(-1px);
  background: var(--orp-cyan);
  color: #FFFFFF;
}

.orphanika-badge--brand {
  background: #EFF6FF;
  color: #1E40AF;
  border: 1px solid #BFDBFE;
}

/* HPO Frequency Help Popover */
.orp-help-popover-trigger {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 18px;
  height: 18px;
  border-radius: 50%;
  background: var(--orp-cyan-light);
  color: var(--orp-primary);
  border: 1px solid var(--orp-cyan);
  font-size: 11px;
  font-weight: 700;
  cursor: pointer;
  padding: 0;
  line-height: 1;
  vertical-align: middle;
  transition: all 0.15s ease;
}

.orp-help-popover-trigger:hover {
  background: var(--orp-cyan);
  color: #FFFFFF;
}

.orp-popover-dialog {
  position: absolute;
  top: 28px;
  left: 0;
  z-index: 100;
  background: #FFFFFF;
  border: 1px solid var(--orp-cyan);
  border-radius: var(--orp-radius-md);
  box-shadow: var(--orp-shadow-lg);
  padding: 16px 20px;
  width: 290px;
  text-align: left;
}

.orp-popover-content h4 {
  margin: 0 0 10px;
  font-size: 0.95rem;
  color: var(--orp-primary);
}

.orp-popover-content ul {
  margin: 0;
  padding-left: 18px;
  font-size: 0.85rem;
  line-height: 1.6;
}

/* Prominent Molecular Target Callout */
.orp-target-callout {
  background: var(--orp-cyan-light);
  border-left: 4px solid var(--orp-cyan);
  padding: 14px 18px;
  border-radius: 0 var(--orp-radius-sm) var(--orp-radius-sm) 0;
  display: flex;
  align-items: center;
  gap: 12px;
}

.orp-target-callout-header {
  font-size: 0.95rem;
  color: var(--orp-primary);
  display: flex;
  align-items: center;
  gap: 6px;
}

.orp-target-callout-value code {
  font-size: 0.95rem;
  background: #FFFFFF;
  padding: 4px 10px;
  border-radius: var(--orp-radius-sm);
  border: 1px solid rgba(123, 164, 181, 0.4);
  color: var(--orp-primary-dark);
  font-weight: 700;
}

/* Hero Jump Link */
.orp-hero-jump-wrap {
  margin-top: 14px;
}

.orp-jump-link {
  color: #FFFFFF !important;
  text-decoration: underline 2px solid var(--orp-cyan) !important;
  text-underline-offset: 3px;
  font-size: 0.92rem;
  font-weight: 600;
  transition: opacity 0.15s ease;
}

.orp-jump-link:hover {
  opacity: 0.85;
}

/* Sidebar Gene Facts List */
.orp-gene-facts-list {
  list-style: none;
  padding: 0;
  margin: 0;
  display: flex;
  flex-direction: column;
  gap: 12px;
}

.orp-gene-fact-item {
  display: flex;
  flex-direction: column;
  gap: 4px;
  padding-bottom: 8px;
  border-bottom: 1px solid rgba(226, 232, 240, 0.7);
}

.orp-gene-fact-item:last-child {
  border-bottom: none;
}

.orp-badge-xs {
  font-size: 0.72rem;
  padding: 2px 8px;
  width: fit-content;
}

/* Collapsible List Chevron Button */
.orp-toggle-wrap {
  margin: 22px 0;
  text-align: center;
}

.orp-btn--toggle {
  background: #FFFFFF;
  border: 1px solid var(--orp-cyan);
  color: var(--orp-primary);
  padding: 10px 24px;
  border-radius: var(--orp-radius-pill);
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 0.9rem;
  cursor: pointer;
  box-shadow: var(--orp-shadow-sm);
  transition: all 0.2s ease;
}

.orp-btn--toggle:hover {
  background: var(--orp-cyan-light);
  border-color: var(--orp-primary);
  color: var(--orp-primary);
  box-shadow: var(--orp-shadow-md);
}

/* Top 30 Rare Diseases Section (Clean Flat List, No Orpha Codes, Grey Bottom Border) */
.orp-home-top-diseases-section {
  padding: 50px 24px 70px;
  background: var(--orp-bg);
  border-top: 1px solid var(--orp-border);
}

.orp-section-header-center {
  text-align: center;
  max-width: 720px;
  margin: 0 auto 36px;
}

.orp-home-section-title {
  font-size: 2.1rem;
  margin-bottom: 8px;
  color: var(--orp-primary);
}

.orp-top-diseases-list {
  list-style: none !important;
  margin: 0 auto !important;
  padding: 0 !important;
  max-width: 1000px;
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 0 40px;
}

@media (max-width: 768px) {
  .orp-top-diseases-list {
    grid-template-columns: 1fr;
  }
}

.orp-top-disease-row {
  list-style: none !important;
  padding: 14px 4px;
  border-bottom: 1px solid #E2E8F0;
  margin: 0 !important;
  transition: background-color 0.15s ease;
}

.orp-top-disease-row:hover {
  background-color: rgba(232, 240, 243, 0.4);
}

.orp-top-disease-link {
  font-size: 1.05rem;
  font-weight: 600;
  color: #1B4965;
  text-decoration: underline 2px solid #7BA4B5;
  text-underline-offset: 3px;
  display: block;
}

.orp-top-disease-link:hover {
  color: #0E2A3A;
  text-decoration-color: var(--orp-accent);
}

/* Homepage Hero Integrated A-Z Bar (Single Line, Flat, Space-Efficient) */
.orp-hero-az-wrap {
  margin-top: 24px;
  width: 100%;
}

.orp-hero-az-wrap .orphanika-az-nav {
  background: rgba(255, 255, 255, 0.85);
  border: 1px solid rgba(47, 72, 88, 0.15);
  border-radius: var(--orp-radius-pill);
  box-shadow: 0 2px 8px rgba(47, 72, 88, 0.05);
  padding: 8px 16px;
  margin: 0 auto;
  max-width: 860px;
  display: flex;
  flex-wrap: nowrap;
  justify-content: space-between;
  align-items: center;
  overflow-x: auto;
  gap: 2px;
}

.orp-hero-az-wrap .orphanika-az-btn {
  min-width: 26px;
  height: 28px;
  padding: 0 4px;
  font-size: 0.85rem;
  font-weight: 700;
  color: var(--orp-primary);
  border-radius: 4px;
  text-decoration: none;
}

.orp-hero-az-wrap .orphanika-az-btn:hover,
.orp-hero-az-wrap .orphanika-az-btn.is-active {
  background: var(--orp-accent);
  color: #FFFFFF;
}

/* About Orphanika & Support (Bootstrap Media Object Pattern + Rounded Rectangle Button) */
.orp-home-about-section {
  padding: 50px 24px 80px;
  background: #FFFFFF;
  border-top: 1px solid var(--orp-border);
}

.orp-media-object {
  max-width: 960px;
  margin: 0 auto;
  display: flex;
  align-items: flex-start;
  gap: 28px;
  padding: 24px 0;
}

@media (max-width: 680px) {
  .orp-media-object {
    flex-direction: column;
    align-items: center;
    text-align: center;
  }
}

.orp-media-figure {
  flex-shrink: 0;
  width: 72px;
  height: 72px;
  background: #E8F0F3;
  border-radius: var(--orp-radius-md);
  display: flex;
  align-items: center;
  justify-content: center;
}

.orp-media-body {
  flex: 1;
}

.orp-about-title {
  font-size: 1.8rem;
  margin: 0 0 12px 0;
  color: var(--orp-primary);
}

.orp-about-text {
  font-size: 1rem;
  line-height: 1.7;
  color: var(--orp-text);
  margin-bottom: 14px;
}

.orp-about-actions {
  margin-top: 20px;
}

/* Rounded Rectangle Button */
.orp-btn-rounded {
  display: inline-block;
  padding: 12px 28px;
  background: var(--orp-accent);
  color: #FFFFFF !important;
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 0.95rem;
  text-decoration: none !important;
  border-radius: 6px; /* Clean rounded rectangle, not a circular pill */
  box-shadow: 0 2px 6px rgba(243, 102, 51, 0.25);
  transition: all 0.15s ease;
}

.orp-btn-rounded:hover {
  background: var(--orp-accent-hover);
  box-shadow: 0 4px 10px rgba(243, 102, 51, 0.35);
  transform: translateY(-1px);
}

/* ==========================================================================
   Archive Directory Pages (Diseases, Symptoms, Drugs, Genes)
   Clean Full-Width View: Breadcrumbs -> Search -> Translated A-Z Index -> Clean List
   Zero sidebars, zero widgets.
   ========================================================================== */

.orp-archive-container {
  max-width: 1200px !important;
  margin: 32px auto 80px !important;
  padding: 0 24px !important;
  width: 100% !important;
  box-sizing: border-box !important;
}

/* 1. Breadcrumbs Navigation */
.orp-archive-breadcrumbs {
  display: flex;
  align-items: center;
  flex-wrap: wrap;
  gap: 8px;
  font-size: 0.88rem;
  color: #64748B;
  margin-bottom: 20px;
}

.orp-breadcrumb-link {
  color: #1B4965;
  text-decoration: none;
  font-weight: 500;
  transition: color 0.15s ease;
}

.orp-breadcrumb-link:hover {
  color: var(--orp-accent);
  text-decoration: underline;
}

.orp-breadcrumb-sep {
  color: #94A3B8;
  font-size: 0.95rem;
  user-select: none;
}

.orp-breadcrumb-current {
  color: #334155;
  font-weight: 600;
}

/* Page Header & Count */
.orp-archive-header {
  margin-bottom: 24px;
}

.orp-archive-title {
  font-family: var(--orp-font-heading);
  font-size: 2.2rem;
  font-weight: 800;
  color: var(--orp-primary);
  letter-spacing: -0.025em;
  margin: 0 0 6px 0;
  line-height: 1.2;
}

.orp-archive-count {
  font-size: 0.95rem;
  color: #64748B;
  margin: 0;
}

/* 2. Integrated Search Bar with Branded Orange Button */
.orp-archive-search-wrap {
  margin-bottom: 24px;
}

.orp-archive-search-input-wrap {
  display: flex;
  align-items: stretch;
  background: #FFFFFF;
  border: 1.5px solid #CBD5E1;
  border-radius: 8px;
  overflow: hidden;
  box-shadow: 0 1px 4px rgba(0, 0, 0, 0.04);
  transition: border-color 0.2s ease, box-shadow 0.2s ease;
}

.orp-archive-search-input-wrap:focus-within {
  border-color: #1B4965;
  box-shadow: 0 0 0 3px rgba(27, 73, 101, 0.12);
}

.orp-archive-search-input {
  flex: 1;
  border: none !important;
  outline: none !important;
  padding: 14px 18px !important;
  font-size: 1rem !important;
  color: #1E293B !important;
  background: transparent !important;
  font-family: inherit;
  box-shadow: none !important;
}

.orp-archive-search-input::placeholder {
  color: #94A3B8;
}

.orp-archive-search-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  gap: 8px;
  background: #F36633 !important;
  color: #FFFFFF !important;
  border: none !important;
  padding: 0 24px !important;
  font-family: var(--orp-font-heading) !important;
  font-weight: 700 !important;
  font-size: 0.95rem !important;
  cursor: pointer;
  transition: background 0.15s ease;
  white-space: nowrap;
  flex-shrink: 0;
}

.orp-archive-search-btn:hover {
  background: #E05320 !important;
}

.orp-archive-search-btn svg {
  stroke: #FFFFFF;
  flex-shrink: 0;
}

/* 3. Translated A-Z Alphabetical Index Bar */
.orp-archive-az-wrap {
  margin-bottom: 32px;
  padding: 14px 18px;
  background: #F8FAFC;
  border: 1px solid #E2E8F0;
  border-radius: 8px;
}

.orp-archive-az-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 10px;
  font-size: 0.85rem;
}

.orp-archive-az-label {
  font-family: var(--orp-font-heading);
  font-weight: 700;
  color: #475569;
  text-transform: uppercase;
  letter-spacing: 0.04em;
}

.orp-az-switch-link {
  color: #1B4965;
  font-weight: 600;
  text-decoration: underline;
  font-size: 0.85rem;
}

.orp-az-switch-link:hover {
  color: var(--orp-accent);
}

.orp-archive-az-nav {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 5px;
}

.orp-az-letter-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 32px;
  height: 32px;
  padding: 0 6px;
  font-family: var(--orp-font-heading);
  font-size: 0.88rem;
  font-weight: 600;
  color: #1B4965;
  background: #FFFFFF;
  border: 1px solid #CBD5E1;
  border-radius: 4px;
  text-decoration: none !important;
  transition: all 0.15s ease;
  user-select: none;
}

.orp-az-letter-btn:hover {
  background: #1B4965;
  color: #FFFFFF !important;
  border-color: #1B4965;
}

.orp-az-letter-btn.is-active {
  background: #F36633 !important;
  color: #FFFFFF !important;
  border-color: #F36633 !important;
  font-weight: 700;
}

/* 4. Clean Item List with Distinct Link Underlines */
.orp-archive-results-wrap {
  width: 100%;
}

.orp-archive-list {
  list-style: none !important;
  margin: 0 !important;
  padding: 0 !important;
  border-top: 1px solid #E2E8F0;
}

.orp-archive-list-item {
  padding: 18px 0;
  border-bottom: 1px solid #E2E8F0;
  list-style: none !important;
}

.orp-archive-item-header {
  display: flex;
  align-items: baseline;
  flex-wrap: wrap;
  gap: 10px;
}

/* Distinct Link Underline (GSK Cyan underline + Deep Slate Navy font) */
.orp-archive-item-link {
  font-family: var(--orp-font-heading);
  font-size: 1.22rem;
  font-weight: 700;
  color: #1B4965 !important;
  text-decoration: underline !important;
  text-decoration-color: #7BA4B5 !important;
  text-decoration-thickness: 2px !important;
  text-underline-offset: 4px !important;
  line-height: 1.35;
  transition: all 0.15s ease;
}

.orp-archive-item-link:hover {
  color: #0E7490 !important;
  text-decoration-color: #0E7490 !important;
}

.orp-archive-item-badge {
  font-size: 0.78rem;
  padding: 3px 8px;
  border-radius: 4px;
  vertical-align: middle;
}

.orp-archive-item-desc {
  margin: 8px 0 0 0;
  font-size: 0.95rem;
  line-height: 1.6;
  color: #475569;
}

/* 5. Pagination */
.orp-archive-pagination {
  margin: 36px 0 20px;
  text-align: center;
  display: flex;
  justify-content: center;
  align-items: center;
  gap: 6px;
  flex-wrap: wrap;
}

.orp-archive-pagination .page-numbers {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-width: 36px;
  height: 36px;
  padding: 0 10px;
  font-family: var(--orp-font-heading);
  font-size: 0.9rem;
  font-weight: 600;
  color: #1B4965;
  background: #FFFFFF;
  border: 1px solid #CBD5E1;
  border-radius: 4px;
  text-decoration: none;
  transition: all 0.15s ease;
}

.orp-archive-pagination .page-numbers:hover {
  background: #1B4965;
  color: #FFFFFF;
  border-color: #1B4965;
}

.orp-archive-pagination .page-numbers.current {
  background: #1B4965;
  color: #FFFFFF;
  border-color: #1B4965;
  font-weight: 700;
}

.orp-archive-pagination .page-numbers.dots {
  border: none;
  background: transparent;
  color: #94A3B8;
}

/* No Results State */
.orp-archive-no-results {
  text-align: center;
  padding: 48px 24px;
  background: #F8FAFC;
  border: 1px dashed #CBD5E1;
  border-radius: 8px;
  margin: 20px 0;
}

@media (max-width: 640px) {
  .orp-archive-title {
    font-size: 1.8rem;
  }
  .orp-archive-search-input-wrap {
    flex-direction: column;
  }
  .orp-archive-search-btn {
    padding: 12px 18px !important;
  }
  .orp-az-letter-btn {
    min-width: 28px;
    height: 28px;
    font-size: 0.8rem;
    padding: 0 4px;
  }
}

/* ==========================================================================
   Responsive Mobile Navigation & Hamburger Menu
   ========================================================================== */
.orp-hamburger-toggle-btn {
  display: none;
  align-items: center;
  justify-content: center;
  width: 38px;
  height: 38px;
  background-color: #FFFFFF;
  border: 1px solid #CBD5E1;
  border-radius: 6px;
  cursor: pointer;
  padding: 0;
  box-shadow: 0 1px 3px rgba(0, 0, 0, 0.04);
  transition: all 0.15s ease;
}
.orp-hamburger-toggle-btn:hover {
  background-color: #EBF3F6;
  border-color: #7BA4B5;
}
.orp-hamburger-icon {
  display: flex;
  flex-direction: column;
  justify-content: space-between;
  width: 18px;
  height: 13px;
}
.orp-hamburger-line {
  display: block;
  width: 100%;
  height: 2px;
  background-color: #2F4858;
  border-radius: 2px;
  transition: all 0.2s ease-in-out;
}
.orp-hamburger-toggle-btn.is-active .orp-hamburger-line:nth-child(1) {
  transform: translateY(5.5px) rotate(45deg);
}
.orp-hamburger-toggle-btn.is-active .orp-hamburger-line:nth-child(2) {
  opacity: 0;
}
.orp-hamburger-toggle-btn.is-active .orp-hamburger-line:nth-child(3) {
  transform: translateY(-5.5px) rotate(-45deg);
}

@media (max-width: 900px) {
  .orp-hamburger-toggle-btn {
    display: inline-flex !important;
  }
  .orp-primary-nav {
    display: none !important;
  }
}

.orp-mobile-nav-drawer {
  display: none;
  width: 100%;
  background: #FFFFFF;
  border-top: 1px solid #E2E8F0;
  border-bottom: 2px solid #E2E8F0;
  padding: 16px 20px;
  box-shadow: 0 10px 25px rgba(47, 72, 88, 0.08);
  position: relative;
  z-index: 998;
  box-sizing: border-box;
}
.orp-mobile-menu {
  list-style: none;
  margin: 0;
  padding: 0;
  display: flex;
  flex-direction: column;
  gap: 4px;
}
.orp-mobile-menu li {
  list-style: none;
  margin: 0;
  padding: 0;
}
.orp-mobile-menu a {
  display: flex;
  align-items: center;
  padding: 10px 14px;
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 1.02rem;
  color: #2F4858;
  text-decoration: none;
  border-radius: 8px;
  transition: all 0.15s ease;
}
.orp-mobile-menu a:hover,
.orp-mobile-menu a:focus {
  background-color: #F1F5F9;
  color: #F36633;
}
.orp-mobile-menu .orp-mobile-support a {
  color: #F36633;
  background-color: #FFF5F2;
  border: 1px solid rgba(243, 102, 51, 0.2);
  margin-top: 6px;
}

/* ==========================================================================
   News Monograph Layout & Unboxed Mobile Styling
   ========================================================================== */
.orp-news-page-container {
  max-width: 1200px;
  margin: 0 auto;
  padding: 30px 24px 80px;
  box-sizing: border-box;
}
.orp-news-article {
  background: #FFFFFF;
  border: 1px solid #E2E8F0;
  border-radius: 14px;
  padding: 36px 40px;
  box-shadow: 0 2px 10px rgba(47, 72, 88, 0.04);
}
.orp-news-headline {
  font-family: var(--orp-font-heading);
  font-size: 1.95rem;
  font-weight: 800;
  color: #2F4858;
  line-height: 1.28;
  margin: 0 0 18px 0;
  letter-spacing: -0.02em;
}
.orp-news-lead-deck {
  font-size: 1.15rem;
  line-height: 1.65;
  color: #1E293B;
  font-weight: 500;
  margin: 0 0 24px 0;
  padding-bottom: 20px;
  border-bottom: 1px solid #E2E8F0;
}
.orp-news-byte-card {
  background: linear-gradient(135deg, #F0F6F8 0%, #FAFCFD 100%);
  border: 1.5px solid #7BA4B5;
  border-radius: 10px;
  padding: 18px 22px;
  margin-bottom: 26px;
}
.orp-news-byte-header {
  display: flex;
  align-items: center;
  gap: 8px;
  margin-bottom: 10px;
}
.orp-news-byte-icon {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 24px;
  height: 24px;
  background: #1B4965;
  color: #FFFFFF;
  border-radius: 9999px;
  font-size: 0.78rem;
  font-weight: 800;
}
.orp-news-byte-title {
  font-family: var(--orp-font-heading);
  font-size: 0.95rem;
  font-weight: 800;
  color: #1B4965;
  margin: 0;
  text-transform: uppercase;
  letter-spacing: 0.03em;
}
.orp-news-byte-content {
  font-size: 0.94rem;
  line-height: 1.62;
  color: #1E333F;
}

/* Community Funnel Banners */
.orp-funnel-banner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 14px;
  border-radius: 10px;
  padding: 14px 18px;
  margin-bottom: 28px;
}
.orp-funnel-banner--linkedin {
  background: #F0F7FB;
  border: 1.5px solid #0077B5;
}
.orp-funnel-banner--telegram {
  background: #F0F9FF;
  border: 1.5px solid #229ED9;
}
.orp-funnel-info {
  display: flex;
  align-items: center;
  gap: 12px;
  flex: 1;
  min-width: 230px;
}
.orp-funnel-icon {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 36px;
  height: 36px;
  border-radius: 8px;
  flex-shrink: 0;
  color: #FFFFFF;
}
.orp-funnel-icon--linkedin {
  background: #0077B5;
}
.orp-funnel-icon--telegram {
  background: #229ED9;
}
.orp-funnel-heading {
  font-family: var(--orp-font-heading);
  font-size: 0.93rem;
  font-weight: 750;
  color: #0C4A6E;
  line-height: 1.3;
}
.orp-funnel-sub {
  font-size: 0.82rem;
  color: #475569;
  margin-top: 2px;
}
.orp-funnel-btn {
  display: inline-flex;
  align-items: center;
  gap: 6px;
  color: #FFFFFF !important;
  font-family: var(--orp-font-heading);
  font-weight: 700;
  font-size: 0.84rem;
  padding: 8px 16px;
  border-radius: 6px;
  text-decoration: none !important;
  white-space: nowrap;
  transition: opacity 0.15s ease;
}
.orp-funnel-btn:hover {
  opacity: 0.92;
}
.orp-funnel-btn--linkedin {
  background: #0077B5;
}
.orp-funnel-btn--telegram {
  background: #229ED9;
}

@media (max-width: 768px) {
  .orp-news-page-container {
    padding: 14px 16px 60px !important;
  }
  .orp-news-article {
    background: transparent !important;
    border: none !important;
    border-radius: 0 !important;
    box-shadow: none !important;
    padding: 0 !important;
  }
  .orp-news-headline {
    font-size: 1.55rem !important;
    line-height: 1.3 !important;
    margin-bottom: 14px !important;
  }
  .orp-news-lead-deck {
    font-size: 1.05rem !important;
    line-height: 1.6 !important;
    margin-bottom: 20px !important;
    padding-bottom: 16px !important;
  }
  .orp-news-byte-card {
    padding: 14px 16px !important;
    margin-bottom: 22px !important;
  }
  .orp-funnel-banner {
    flex-direction: column !important;
    align-items: flex-start !important;
    padding: 14px 16px !important;
  }
  .orp-funnel-btn {
    width: 100% !important;
    justify-content: center !important;
  }
}

/* ==============================================================================
   RECENT CLINICAL NEWS SLIDER (ZERO-DEPENDENCY CSS SCROLL-SNAP)
   ============================================================================== */
.orp-news-slider-section {
  background: #F0F6F9;
  border-top: 1px solid #E2E8F0;
  border-bottom: 1px solid #E2E8F0;
  padding: 44px 0 48px;
  width: 100%;
  box-sizing: border-box;
}

.orp-news-slider-container {
  max-width: 1200px;
  margin: 0 auto;
  padding: 0 24px;
  box-sizing: border-box;
}

.orp-news-slider-header-row {
  display: flex;
  align-items: flex-end;
  justify-content: space-between;
  gap: 20px;
  margin-bottom: 22px;
}

.orp-news-slider-title-wrap {
  flex: 1;
}

.orp-news-slider-title {
  font-family: 'Plus Jakarta Sans', sans-serif;
  font-size: 1.55rem;
  font-weight: 700;
  color: #1B4965;
  margin: 0 0 6px 0;
  line-height: 1.25;
}

.orp-news-slider-subtitle {
  font-size: 0.95rem;
  line-height: 1.45;
  color: #64748B;
  margin: 0;
}

.orp-news-slider-controls {
  display: flex;
  align-items: center;
  gap: 10px;
  flex-shrink: 0;
}

.orp-slider-nav-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 42px;
  height: 42px;
  border-radius: 50%;
  background: #FFFFFF;
  border: 1.5px solid #CBD5E1;
  color: #1B4965;
  cursor: pointer;
  transition: all 0.2s cubic-bezier(0.16, 1, 0.3, 1);
  box-shadow: 0 2px 6px rgba(27, 73, 101, 0.05);
  padding: 0;
}

.orp-slider-nav-btn:hover {
  background: #1B4965;
  color: #FFFFFF;
  border-color: #1B4965;
  box-shadow: 0 4px 12px rgba(27, 73, 101, 0.2);
  transform: translateY(-1px);
}

.orp-slider-nav-btn:active {
  transform: translateY(0);
}

.orp-news-slider-track {
  display: flex;
  gap: 20px;
  overflow-x: auto;
  scroll-snap-type: x mandatory;
  scroll-behavior: smooth;
  -webkit-overflow-scrolling: touch;
  padding: 8px 4px 22px;
  margin: 0 -4px;
  scrollbar-width: none;
}

.orp-news-slider-track::-webkit-scrollbar {
  display: none;
}

.orp-news-slide {
  scroll-snap-align: start;
  flex: 0 0 calc((100% - 40px) / 3.25);
  min-width: 0;
  display: flex;
}

.orp-news-slide-card {
  background: #FFFFFF;
  border: 1px solid #E2E8F0;
  border-radius: 12px;
  box-shadow: 0 4px 14px rgba(27, 73, 101, 0.06);
  display: flex;
  flex-direction: column;
  width: 100%;
  overflow: hidden;
  transition: transform 0.2s ease, box-shadow 0.2s ease;
}

.orp-news-slide-card:hover {
  transform: translateY(-4px);
  box-shadow: 0 10px 24px rgba(27, 73, 101, 0.12);
}

.orp-news-card-thumb-link {
  display: block;
  position: relative;
  aspect-ratio: 16 / 9;
  overflow: hidden;
  background: #EBF2F7;
}

.orp-news-card-img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  transition: transform 0.35s ease;
  display: block;
}

.orp-news-slide-card:hover .orp-news-card-img {
  transform: scale(1.04);
}

.orp-news-card-fallback-thumb {
  width: 100%;
  height: 100%;
  display: flex;
  align-items: center;
  justify-content: center;
  background: linear-gradient(135deg, #E3EEF4 0%, #D4E6F1 100%);
  font-size: 2.2rem;
}

.orp-news-card-body {
  padding: 18px 20px 20px;
  display: flex;
  flex-direction: column;
  flex: 1;
}

.orp-news-card-title {
  font-family: 'Plus Jakarta Sans', sans-serif;
  font-size: 1.1rem;
  font-weight: 700;
  line-height: 1.35;
  margin: 0 0 10px 0;
  display: -webkit-box;
  -webkit-line-clamp: 2;
  -webkit-box-orient: vertical;
  overflow: hidden;
}

.orp-news-card-title a {
  color: #1B4965;
  text-decoration: none;
  transition: color 0.2s;
}

.orp-news-card-title a:hover {
  color: #028090;
}

.orp-news-card-meta {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 8px;
  margin-bottom: 12px;
  font-size: 0.8rem;
}

.orp-news-card-date {
  color: #64748B;
  font-weight: 500;
}

.orp-news-card-badge {
  font-size: 0.72rem;
  padding: 2px 7px;
  border-radius: 4px;
  text-transform: uppercase;
  font-weight: 600;
}

.orp-news-card-excerpt {
  font-size: 0.88rem;
  line-height: 1.5;
  color: #475569;
  margin: 0 0 16px 0;
  flex: 1;
  display: -webkit-box;
  -webkit-line-clamp: 3;
  -webkit-box-orient: vertical;
  overflow: hidden;
}

.orp-news-card-link {
  font-family: 'Plus Jakarta Sans', sans-serif;
  font-size: 0.88rem;
  font-weight: 700;
  color: #028090;
  text-decoration: none;
  display: inline-flex;
  align-items: center;
  gap: 4px;
  margin-top: auto;
  transition: gap 0.2s ease, color 0.2s ease;
}

.orp-news-card-link:hover {
  color: #015963;
  gap: 7px;
}

@media (max-width: 992px) {
  .orp-news-slide {
    flex: 0 0 calc((100% - 20px) / 2.25);
  }
}

@media (max-width: 640px) {
  .orp-news-slider-section {
    padding: 34px 0 38px;
  }
  .orp-news-slider-container {
    padding: 0 16px;
  }
  .orp-news-slider-title {
    font-size: 1.3rem;
  }
  .orp-news-slider-controls {
    display: none;
  }
  .orp-news-slider-track {
    gap: 14px;
    padding-bottom: 16px;
  }
  .orp-news-slide {
    flex: 0 0 82%;
  }
}